How can I remove duplicate rows?

What is the best way to remove duplicate rows from a fairly large SQL Server table (i.e. 300,000+ rows)?

The rows, of course, will not be perfect duplicates because of the existence of the RowID identity field.

MyTable

RowID int not null identity(1,1) primary key,
Col1 varchar(20) not null,
Col2 varchar(2048) not null,
Col3 tinyint not null

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