What issues would you face if you use Nginx

WordPress is quite a memory hog, and I’ve been thinking of using nginx rather than apache.

The one major consideration before doing that is if there are any plugins which will stop working. I have tested a few and they seem to work, but I need to find out if there are any which might break.

I unfortnately have no experience with this but evidently it can be done as these articles and plugins address some of the issues:

• HOWTO: Install WordPress On Nginx
• WordPress + nginx Compatibility Plugin
• Howto nginx + wordpress + ubuntu shortest setup
• Nginx front-end proxy cache for WordPress
• WordPress Pretty Permalinks with Nginx
• WordPress, Nginx and WP Super Cache

Also are you familiar with WP Engine WordPress hosting? They are evidently using it in a hybrid form with Apache, probably as a front-end proxy.

• Back in Startup Mode… Announcing WP Engine!

Hope these help.