boto3 client NoRegionError: You must specify a region error only sometimes

I have a boto3 client :

boto3.client('kms')

But it happens on new machines, They open and close dynamically.

    if endpoint is None:
        if region_name is None:
            # Raise a more specific error message that will give
            # better guidance to the user what needs to happen.
            raise NoRegionError()

Why is this happening? and why only part of the time?