Should conda, or conda-forge be used for Python environments?

Conda and conda-forge are both Python package managers. What is the appropriate choice when a package exists in both repositories? Django, for example, can be installed with either, but the difference between the two is several dependencies (conda-forge has many more). There is no explanation for these differences, not even a simple README.

Which one should be used? Conda or conda-forge? Does it matter?

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