I have a very similar problem as described here.
I also upgraded a mixed solution of C++/CLI and C# projects from Visual Studio 2008 to Visual Studio 2010. And now in Visual Studio 2010 one C++/CLI project always runs out of date.
Even if it has been compiled and linked just before and F5 is hit, the messagebox “The project is out of date. Would you like to build it?” appears. This is very annoying because the DLL file is very low-tiered and forces almost all projects of the solution to rebuild.
My pdb settings are set to the default value (suggested solution of this problem).
Is it possible the get the reason why Visual Studio 2010 forces a rebuild or thinks a project is up to date?
Any other ideas why Visual Studio 2010 behaves like that?