Calculate MD5 checksum for a file

I’m using iTextSharp to read the text from a PDF file. However, there are times I cannot extract text, because the PDF file is only containing images. I download the same PDF files everyday, and I want to see if the PDF has been modified. If the text and modification date cannot be obtained, is a MD5 checksum the most reliable way to tell if the file has changed?

If it is, some code samples would be appreciated, because I don’t have much experience with cryptography.

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