Difference between Lookup() and Dictionary(Of list())

I’m trying to wrap my head around which data structures are the most efficient and when / where to use which ones.

Now, it could be that I simply just don’t understand the structures well enough, but how is an ILookup(of key, ...) different from a Dictionary(of key, list(of ...))?

Also where would I want to use an ILookup and where would it be more efficient in terms of program speed / memory / data accessing, etc?

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